Dr. Gupta served in the Indian Defence Accounts Service, where she held various positions including that of Secretary Defence Finance. She was the Principal Adviser(Finance) Organizing Committee Commonwealth Games from September 2005 to November 2008. She served as Additional Secretary, Ministry of Women and Child Development from November 2008 to September 2009. She was a Member Finance Telecom Commission from September 2009 till March 2011.
As Secretary Defence Finance, Dr. Gupta has been involved at the policy-making level in the development of the architecture for fast and transparent adoption of modern weapons and platforms. She was awarded Colonel Pyara Lal Gold Medal for the Best Thesis in the 39th National Defence College (NDC) Course on Defence and Industry Interface in R&D and Production for Achieving Self Reliance in Military Hardware/Software.
Dr. Gupta was the chairperson of the Inter Ministerial Committee for auctioning of the 3G and Broadband Wireless Access Spectrum which involved 183 rounds of bidding across service areas. The e-auction was a benchmark auction yielding a revenue of three times the estimated amount.